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American Society of Microbiology ABMM Sample Questions:

1. A microbiology laboratory is processing a throat swab for the detection of Group A Streptococcus. Culture on sheep blood agar reveals beta-hemolytic colonies. Which of the following tests can be used to presumptively identify Streptococcus pyogenes?

A) Bacitracin susceptibility
B) Bile esculin hydrolysis
C) Catalase test
D) Coagulase test

2. During a primary infection with Epstein-Barr virus (EBV), the virus establishes latency in B lymphocytes.
The transition from lytic to latent infection is tightly regulated by viral gene expression. Which of the following viral proteins is crucial for the establishment and maintenance of EBV latency and is a key target in EBV-associated lymphomas?

A) Epstein-Barr nuclear antigen 1 (EBNA1)
B) Viral capsid antigen (VCA)
C) Glycoprotein gp350
D) Early antigen (EA)

3. A clinical isolate of Klebsiella pneumoniae from a patient with a refractory urinary tract infection exhibits resistance to carbapenems (imipenem, meropenem, ertapenem). PCR analysis reveals the presence of the blaKPC gene. Which of the following enzymatic mechanisms is responsible for this resistance?

A) Efflux of the carbapenem antibiotic out of the bacterial cell.
B) Hydrolysis of the beta-lactam ring, leading to an inactive antibiotic derivative.
C) Trapping of the carbapenem molecule by a decoy protein.
D) Modification of the ribosomal target site, preventing antibiotic binding.

4. A patient presents with a pruritic rash consisting of raised, serpiginous tracks on their skin. The patient recently returned from a Caribbean vacation and reported walking barefoot on the beach. The MOST likely causative organism is:

A) Pediculus humanus
B) Larvae of Ancylostoma braziliense
C) Larvae of Strongyloides stercoralis
D) Sarcoptes scabiei

5. Which of the following viruses is an enveloped, double-stranded DNA virus known to cause latent infections often reactivated during immunosuppression?

A) Poliovirus
B) Influenza A virus
C) Cytomegalovirus (CMV)
D) Rotavirus

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